Basic Molecular Information

Basic Information

DICL ID
DICL_CP_0319565
PubChem CID
Molecular Formula
C16H16N4
Molecular Weight
264.332 g/mol
Synonyms/Alias
[CHEMBL4798572; BDBM50553736]
InChI Key
GYSKOUFUCVGMOT-UHFFFAOYSA-N
InChI
InChI=1S/C16H16N4/c1-2-4-13(5-3-1)19-16-8-15-14(9-17-16)18-11-20(15)10-12-6-7-12/h1-5,8-9,11-12H,6-7...
IUPAC Name
1-(cyclopropylmethyl)-N-phenylimidazo[4,5-c]pyridin-6-amine
CAS Number
N/A (Not available)

Structure Information

Chemical Structure Visualization

SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF

36 39 0 0 0 0 0 0 0 0999 V2000
-2.8950 1.5872 -2.4424 C 0 0 0 0 0 0 0 0 0 0 0 0
-3.6545 1.2477 -1.1684 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.2321 0.746...

Experimental Data

Activity Data

Target Ion Channel
Gamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2
Uniprot Accession Number
Function
Allosteric Modulator
Species
Rattus norvegicus (Rat)
IC50
N/A (Not available)
EC50
N/A (Not available)
Ki
Ki: 972 nM
Kd
N/A (Not available)
Inhibition
N/A (Not available)

Experimental Conditions

pH
Not mention
Holding Potential
Not specified
Temperature
Not mention
Test Method
Binding assay ([3H] Ro15-1788)
Test Species
Not specified

Binding Information

Binding Site
Extracellular domain
Binding Site Residue
Benzodiazepine binding site

Disease Information

Related Disease
treatment of cognitive disorders

References

URL
N/A (Not available)
PMID
Patent
N/A (Not available)

Computed Properties

Heavy Atom Count
20
Rotatable Bonds
4
logP
3.5849
Complexity
79.9767
TPSA (Ų)
42.74
H-Bond Donors
1
H-Bond Acceptors
4
Ring Count
4
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